Aufgrund der neuen rechtlichen Situation für Online-Plattformen, wurde das Forum am 15.02.24 geschlossen. Das Projekt selber wird intern weitergeführt. Infos hier: KLICK

ICD Code Verfahren, unsere Beiträge sind gefordert! Infos hier: KLICK

Fluorierte Medikamente können zu Fluoracetat verstoffechselt werden

spacerat
Beiträge: 341
Registriert: 07.11.2016, 17:40

Fluorierte Medikamente können zu Fluoracetat verstoffechselt werden

#1644

Beitragvon spacerat » 14.09.2017, 17:39

unnamed (3).png
unnamed (3).png (66.94 KiB) 4691 mal betrachtet
unnamed (3).png
unnamed (3).png (66.94 KiB) 4691 mal betrachtet


Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity.

Murphy CD1, Sandford G.

Abstract
INTRODUCTION:
Fluorine's unique physicochemical properties make it a key element for incorporation into pharmacologically active compounds. Its presence in a drug can alter a number of characteristics that affect ADME-Tox, which has prompted efforts at improving synthetic fluorination procedures.
AREAS COVERED:
This review describes the influence of fluorine on attributes such as potency, lipophilicity, metabolic stability and bioavailablility and how the effects observed are related to the physicochemical characteristics of the element. Examples of more recently used larger scale synthetic methods for introduction of fluorine into drug leads are detailed and the potential for using biological systems for fluorinated drug production is discussed.
EXPERT OPINION:
The synthetic procedures for carbon-fluorine bond formation largely still rely on decades-old technology for the manufacturing scale and new reagents and methods are required to meet the demands for the preparation of structurally more complex drugs. The improvement of in vitro and computational methods should make fluorinated drug design more efficient and place less emphasis on approaches such as fluorine scanning and animal studies. The introduction of new fluorinated drugs, and in particular those that have novel fluorinated functional groups, should be accompanied by rigorous environmental assessment to determine the nature of transformation products that may cause ecological damage.

https://www.ncbi.nlm.nih.gov/pubmed/25728479

Zurück zu „Fluoracetat - Vergleichstheorie“

Wer ist online?

Mitglieder in diesem Forum: 0 Mitglieder und 3 Gäste